Ther-Biotic InterFase Plus combines the same unique enzyme formulation found in InterFase® with ethylenediaminetetraacetic acid (EDTA). The presence of calcium, iron, and magnesium is essential for biofilm creation and serves to cross-link the anionic regions of polymers. InterFase® Plus includes EDTA which binds the metals needed for biofilm formation. InterFase® Plus can be used for maximum antibiofilm activity.*